Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
USERS' SCORE
Good
Based on 140 Reviews
8.3
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1.5 g
<1%**
Total Sugars
1.5 g
†
D-Mannose
1.5 g (1,500 mg)
†
Top Medical Research Studies
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
Read More
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
Read More
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Read More
Most Useful Reviews
7.5
Effective treatment
423 people found this helpful
After trying LifeSeasons, Urinari-X, I opted for D-mannose and Cranberries due to persistent cystitis linked to my autoimmune disorder. I found these alternatives to be cost-effective and lasted longer. By taking one of each tablet twice daily throughout winter, I avoided severe attacks. This treatment truly deserves a high rating.
Read More
10
Remarkable results
171 people found this helpful
After suffering with cystitis for over 10 years, I finally found relief. Antibiotics frequently failed to help, but D-mannose proved effective against my recurring autoimmune disorder. I took three capsules daily at the first signs of trouble, successfully preventing exacerbations. I wholeheartedly recommend D-mannose—it's a miracle for those afflicted.
Read More
9
Significant improvement
165 people found this helpful
After years of chronic cystitis and countless antibiotic injections, I persuaded my mother to use D-mannose, alongside probiotics and other supplements for her autoimmune disorder. Miraculously, she experienced significant improvements in her condition. The frequency of cystitis attacks reduced, and her overall gut health improved. A truly effective natural remedy.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
- All Researches
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
Read More
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Read More
9
We explored how engineered antibodies using mannose 6-phosphate analogs can enhance treatment for autoimmune and inflammatory disorders. Through a clever design, these antibodies target both harmful proteins and specific receptors on cells, which allows for greater internalization and degradation of these proteins.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
Read More
9
We explored an innovative approach to treating rheumatoid arthritis (RA) using mannose-targeted methotrexate delivery systems. This strategy involved creating chimaeric polymersomes that deliver higher amounts of methotrexate directly to macrophages.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
Read More
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
Read More
User Reviews
USERS' SCORE
Good
Based on 140 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective treatment
423 people found this helpful
After trying LifeSeasons, Urinari-X, I opted for D-mannose and Cranberries due to persistent cystitis linked to my autoimmune disorder. I found these alternatives to be cost-effective and lasted longer. By taking one of each tablet twice daily throughout winter, I avoided severe attacks. This treatment truly deserves a high rating.
Read More
10
Remarkable results
171 people found this helpful
After suffering with cystitis for over 10 years, I finally found relief. Antibiotics frequently failed to help, but D-mannose proved effective against my recurring autoimmune disorder. I took three capsules daily at the first signs of trouble, successfully preventing exacerbations. I wholeheartedly recommend D-mannose—it's a miracle for those afflicted.
Read More
9
Significant improvement
165 people found this helpful
After years of chronic cystitis and countless antibiotic injections, I persuaded my mother to use D-mannose, alongside probiotics and other supplements for her autoimmune disorder. Miraculously, she experienced significant improvements in her condition. The frequency of cystitis attacks reduced, and her overall gut health improved. A truly effective natural remedy.
Read More
9
Sustained relief
109 people found this helpful
After enduring severe cystitis following my autoimmune disorder, I relied heavily on antibiotics. However, incorporating D-mannose with cranberry extract changed everything. I took a loading dose at the first hint of discomfort, and I’ve remained symptom-free for six months. I highly recommend trying this approach to manage cystitis.
Read More
9
Life-changing remedy
87 people found this helpful
D-mannose has been my miracle cure! I’ve suffered from cystitis for years, with antibiotics providing only temporary relief. This supplement dramatically improved my condition linked to an autoimmune disorder, allowing me to enjoy a fulfilling marriage and regain normalcy. It's a game changer—highly recommended!
Read More
Frequently Asked Questions
9
Long-term success
24 people found this helpful
Suffering from cystitis for over 15 years due to an autoimmune disorder, I turned to D-mannose as a last resort. To my surprise, within days of starting it, all my symptoms vanished. I haven't felt any discomfort for months and have just ordered more. I highly recommend trying this!
9
Rapid results
4 people found this helpful
After much thought, I ordered D-mannose and was relieved to find that it alleviated my acute inflammation in just 2-3 days! I didn’t expect such swift results, and it truly works wonders for my autoimmune disorder.
9
Effective treatment
10 people found this helpful
I’ve suffered from chronic autoimmune disorder, cystitis, for years. I tried d-mannose with doubt, but after a month—even after being cold—I had no flare-ups! I plan to continue with this as it seems effective, and I’m very pleased.
9
Significant improvement
165 people found this helpful
After years of chronic cystitis and countless antibiotic injections, I persuaded my mother to use D-mannose, alongside probiotics and other supplements for her autoimmune disorder. Miraculously, she experienced significant improvements in her condition. The frequency of cystitis attacks reduced, and her overall gut health improved. A truly effective natural remedy.
9
Sleep improved
4 people found this helpful
I frequently suffer from cystitis, so I decided to try D-mannose for prevention. Within two days, I noticed reduced bathroom visits at night, greatly improving my sleep despite my longstanding issues related to my autoimmune disorder.
9
Life-changing remedy
87 people found this helpful
D-mannose has been my miracle cure! I’ve suffered from cystitis for years, with antibiotics providing only temporary relief. This supplement dramatically improved my condition linked to an autoimmune disorder, allowing me to enjoy a fulfilling marriage and regain normalcy. It's a game changer—highly recommended!
9
Sustained relief
109 people found this helpful
After enduring severe cystitis following my autoimmune disorder, I relied heavily on antibiotics. However, incorporating D-mannose with cranberry extract changed everything. I took a loading dose at the first hint of discomfort, and I’ve remained symptom-free for six months. I highly recommend trying this approach to manage cystitis.
9
Cystitis relief
5 people found this helpful
This remedy has been my salvation from cystitis caused by E. coli! I've been taking it with cranberries for over two years after each encounter, and I haven’t had a relapse. My doctors couldn't help, but this product has allowed me to live without the routine discomfort associated with my autoimmune disorder.
10
Remarkable results
171 people found this helpful
After suffering with cystitis for over 10 years, I finally found relief. Antibiotics frequently failed to help, but D-mannose proved effective against my recurring autoimmune disorder. I took three capsules daily at the first signs of trouble, successfully preventing exacerbations. I wholeheartedly recommend D-mannose—it's a miracle for those afflicted.
9
Sustained relief
6 people found this helpful
I have long suffered from cystitis despite trying various medications. My doctor recommended D-mannose, which has proven effective. I take 500 mg twice daily, free from symptoms during the course. It's herbal, and safe, even for pregnant women. I’m very satisfied with this product.
9
Symptoms alleviated
5 people found this helpful
First order with iHerb and I'm now a permanent customer! After researching, I discovered D-mannose and its beneficial effects on cystitis caused by an autoimmune disorder. I ordered it together with Cranberry Concentrate and after just three days of taking them, all symptoms disappeared! Now I take this combination twice a year for prevention.
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
9
We explored an innovative approach to treating rheumatoid arthritis (RA) using mannose-targeted methotrexate delivery systems. This strategy involved creating chimaeric polymersomes that deliver higher amounts of methotrexate directly to macrophages.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
References
- Lu Y, Xiong Y, Zhang S, Wang B, Feng Y, et al. D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis. Front Pharmacol. 2024;15:1454713. 10.3389/fphar.2024.1454713
- Zhao YL, Li ZX. [Therapeutic potential of EAE mice with sodium oligomannate and effects of intestinal flora and microglia polarization]. Zhonghua Yi Xue Za Zhi. 2024;104:1521. 10.3760/cma.j.cn112137-20231114-01087
- Daurat M, Gauthier C, El Cheikh K, Ali LMA, Morère E, et al. Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins. Front Immunol. 2024;15:1273280. 10.3389/fimmu.2024.1273280
- Jiang Q, Wei B, You M, Zhou X. d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice. Int Immunopharmacol. 2023;118:110087. 10.1016/j.intimp.2023.110087
- Yang L, Sha Y, Wei Y, Fang H, Jiang J, et al. Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy. Biomater Sci. 2023;11:2211. 10.1039/d2bm02072f
